screeb's Blog

Source: Treating C-IBS low motility with a Nutritional Supplement (Garcinia Cambogia)

Source: Treating C-IBS low motility with a Nutritional Supplement (Garcinia Cambogia)

Source: Treating C-IBS low motility with a Nutritional Supplement (Garcinia Cambogia)

Proximal colon distension causes decreased gastric emptying (increased gastric stasis time in the stomach).        The decreased gastric emptying pathway is blocked by systemic capsaicin.  Capsaicin-sensitive vagal afferent neurons contribute to the detection of pathogenic bacterial colonization in the gut, (which can reduce inflammation and dis...

Insulin is known to regulate nitric oxide (NO) production by activating eNOS (endothelial Nitric Oxide Synthase).  Increased generation of NO is a consequence of Insulin Resistance, which produces more insulin.  This causes relaxation of vascular smooth muscle and acts predominantly on venous (capacitance) vessels.  The lack of change in he...

Mechanisms Involved in stress-induced modulation of visceral pain. Pathological pain refers to conditions characterized by hyperalgesia and allodynia, in which maladaptive neuroplastic changes lead to persistent increased perception and responsiveness to noxious stimuli, or response to normally non-noxious stimuli.  Such neuroplastic changes can...

Source: Pain in rectum

 ,  . The mucosa in the GI tract is subject to large variations in blood perfusion, and therefore PO2. During fasting, (Gastroparesis or delayed gastric emptying), the blood flow is low (5% of cardiac output) which then rises significantly to 30% after a meal. In addition, the mucosa has a steep oxygen gradient from the epithelial cells adj...

Abstract -- Delayed gastric emptying (GE) is called gastroparesis (associated with Irritable Bowel Syndrome -constipation). The following procedure was developed to produce gastric emptying. Drinking coffee is a pre-requisite for the anti-gastro paretic effects of the procedure. The procedure, in a nutshell, is this: for one hour after taking coffee and r...

Coffee causes decreased blood glucose, and when glucose concentrations in the brain fall, there are interneurons that connect the brain’s cortex to its thalamus, causing increased epinephrine release. Increased plasma epinephrine (adrenaline) leads to upper GI motility. Microbial metabolism of dietary carbohydrates results mainly in the formation of...