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From: A different approach. Please let me know if you have tried this.

Posted by screeb , 04 June 2013 · 1,218 views

What I do to keep my stools from getting too dry and compacted is to take garcinia cambogia, which has a citric acid extract.
A redox reaction in citric acid is the first step of the electron transport chain (Kreb's Cycle) in the mitochondria of the cytoplasm of a cell.   When one takes a Garcinica Cambogia (GC) pill, which consists of 60% Hydroxycitric acid (HCA), there is a “left shift “ or “turning on” of the mitochondria of the endoplasmic reticulum.  Garcinia cambogia causes HIF-1 reduction.
I belive G. Cambogia is helping prevent stools from drying out by reducing Hypoxia Factor Inducible 1 (HIF-1) genes.  Hypoxia-inducible factor-1 alpha (HIF-1alpha) functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes whose protein products increase oxygen delivery. The carotid body, a peripheral chemosensor no bigger than a grain of rice, is the most perfused organ per gram weight in the body and receives blood via an arterial branch arising from internal or external carotid artery. A proposed underlying mechanism for hyperactivity of the chemoreceptors is the relative activity of HIF-1 alpha.[i] Increased HIF-1 alpha-dependent NOX2 mRNA expression, triggers glomus cell depolarization (type of cell in Carotid Body), leading to sympathetic activation.[ii]
However, Garcinia Cambogia causes decreased activation of HIF-1 causing decreased sympathetic activation such that less pain projects from gut pathway causing decreased Locus coeruleus firing causing decreased perception of visceral pain. The less intense the pain pathway "whispers down the lane",  the less the level of norepinephrine in the brain and therefore G. Cambogia which produces decreased HIF-1 is decreasing norepinephrine where the major effect is a decrease in perception of visceral pain . Combining these two sub-programs into a super program , the G. Cambogia decreases HIF-1, causing increased sugar causing decreased LHA/OX-A, causing reduced peristalsis via decreased dorsal motor nucleus of the vagus activation.  The vagal or parasympathetic system balances out the norepinephrine/sympathetic system. Remember, we are dealing in long term overactivity of the proximal colon, so reducing peristalsis (proximal colon activity) is a good thing. It makes the stools less compressed and dryed out.

Source: A different approach. Please let me know if you have tried this.


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