I really didnt notice any side effects besides the sleepiness.. The first day was fun, felt like I was walking in a dream.. it was kind of silly and not completely unnerving. Besides it knocking you out about an hour and a half after taking it (play the game how long can I stay up after taking a a seroquel... my record is 2 hours.. and I couldnt remember the end of the night the next day lol.) it gives you a bit of a hangover the next morning. It can be hard to wake up some days. It also makes me crave sweets like there is no tomorrow. It also makes me soooo thirsty when I wake up in the morning.. Seriously though, after suffering from anxiety and insomnia off and on my whole life, seroquel is amazing.. No more having to worry about being able to sleep at night, not keeping myself awake from worrying or obsessing.. It also calmed my anxiety down a little bit which is nice. Here is what crazymeds says about seroquel side effects, keep in mind that youd be taking a really low dosage so chances are you wont get many of them (Im on 25mg, for treating psychotics its like 300mg) Seroquel (quetiapine fumarate) is notorious for two things - making you sleep until next Tuesday, and giving you a hangover when you eventually wake up. For 90% or so of the people who take it, the hangover goes away in two or three days, a week at the outside. And if you're taking Seroquel as required for sleep, the hangover often goes away eventually. It all depends on how often you take it. Otherwise expect the usual short-term side effects for atypical antipsychotics - headache, nausea, dry mouth, sleepiness or insomnia, diarrhea or constipation, not giving a damn about anything (a.k.a. the zombification effect). Most, if not all of these will go away in a couple of weeks. Except for the excessive sleepiness, which could hang around for as long as you take this med. The other big issue with a lot of people is weight gain. While not as bad as Zyprexa (olanzapine), like that med Seroquel is a potential triple threat when it comes to weight gain, as it could slow your metabolism, may make you want to sleep 10 or more hours a day, and often make you want to eat more. And since it hits the H1 histamine receptor, and hard, (see How Seroquel Works for details) it's going to make you crave carbohydrates like there's no tomorrow, so good luck sticking to that Atkins diet. But, hey, at least it's the goddamn med's fault and not any lack of willpower on your part.