Posted 04 May 2010 - 01:08 PM
One of the other users, idkwia, was telling about this guy in Australia who claims quite a lot of digestive disorders are actually caused by bacterial overgrowth/infection with a specific agent. Check his website out at http://www.cdd.com.a...nstipation.html
He says:"At the Centre for Digestive Diseases long standing research in this area has indicated that the most likely cause of the common variety constipation found in the majority of patients is caused by an infection with a bacterial agent that has entered the bowel through the mouth and has begun to coexist with normal human bowel flora. Its presence in the bowel flora is marked by the production of molecules within the bowel which affect the enteric nervous system so partially paralysing the bowel. If the constipation agent produces severe paralysis the bowel may not empty for days or weeks. Most commonly very mild forms are present and people tend to overcome this with simple methods such as excessive fibre or even chemical laxatives such as naturally occurring teas which may contain senna. However, worldwide the research on constipation has been extremely slow because it has been hidden by an overwhelming belief both in the lay and medical population that it is the lack of fibre which causes constipation. We now know that nothing can be further from the truth since removal of fibre from the diet of healthy patients does not cause constipation.The actual causative agent or agents are yet to be detected. However it appears that constipation is almost certainly caused by agents which respond to antibiotics which also kill clostridia. So there is a high chance that a type of a clostridium (clostridia produced neuro-toxins (e.g. Clostridium tetuni, Clostridium botulinum, Clostridium difficile, Clostridium perfringens) and so constipation may be simply a chronic infection with a clostridium that carries a spore and so it is difficult to eradicate with antibiotics. The most powerful evidence for this is published indication that Vancomycin which is not absorbed in the GI tract when taken by mouth, can dramatically reverse constipation. [The effect of oral vancomycin on chronic idiopathic constipation. Aliment Pharmacol Ther 1995/9:63-68) Vancomycin] Vancomycin can be combined with other agents such as Metronidazole or Rifampicin to strengthen the affect upon a constipating agent and to give the patients relief from there straining and bloating. Interestingly, the paralysis of the large bowel may be accompanied by partial paralysis of the small bowel so preventing gas moving forward and causing bloating. Such circulating active molecules produced in the colonic flora can also partially paralyse the stomach and this causes Gastroparesis and in some patients vomiting and also paralyses the lower oesophageal sphincter causing reflux. In a subset of patients’ partial paralysis of the gall bladder causes reduced ejection of bile, precipitation of cholesterol and formation of gall stones.This generalised motility inhibition in the GI tract with one or two geographical areas in the GI tract posing as the symptom inducing area – has puzzled researchers for many years. Diet, allergy, stress and other mechanisms have been invoked to explain all of this. However in patients who respond very well to specialised antibiotics such as Vancomycin or Rifampicin combination the reversal of dysmotility is so dramatic that it is quite clear that the bowel flora plays the major role in this common and chronic condition."Quite a claim. He also uses something called faecal bacteriotherapy - http://en.wikipedia....bacteriotherapy
He says:"The intestinal flora may play a key role in the pathogenesis of certain gastrointestinal (GI) diseases. Components of bowel flora such as Lactobacillus acidophilus and Bifidobacterium bifidus have long been used empirically as therapeutic agents for GI disorders. More complex combinations of probiotics for therapeutic bacteriotherapy have also recently become available, however the most elaborate mix of human-derived probiotic bacteria is, by definition, the entire fecal flora. Fecal bacteriotherapy uses the complete normal human flora as a therapeutic probiotic mixture of living organisms. This type of bacteriotherapy has a longstanding history in animal health and has been used sporadically against chronic infections of the bowel, especially as a treatment of last resort for patients with severe Clostridium difficile syndromes including recurrent diarrhea, colitis, and pseudomembranous colitis. Encouraging results have also been observed following infusions of human fecal flora in patients with inflammatory bowel disease, irritable bowel syndrome, and chronic constipation. The therapeutic use of fecal bacteriotherapy is reviewed here and possible mechanisms of action and potential applications explored. Published reports on fecal bacteriotherapy are few in number, and detail the results of small uncontrolled open studies and case reports. Nevertheless, given the promising clinical responses, formal research into fecal bacteriotherapy is now warranted."I'm holding off judgement til I read his full length published research. I do wish he wasn't in Australia.