PubMed- The Confluence of Increased Permeability, Inflammation, and Pain in Irritable Bowel Syndrome.
Posted 28 July 2012 - 08:22 AM
The Confluence of Increased Permeability, Inflammation, and Pain in Irritable Bowel Syndrome.
Am J Physiol Gastrointest Liver Physiol. 2012 Jul 26;
Authors: Camilleri M, Lasch K, Zhou W
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal ailments among those seeking health care for gastrointestinal disorders. Despite its prevalence, IBS pathophysiology is still not completely understood. Continued elucidation of IBS etiologic mechanisms will lead to a greater appreciation of possible therapeutic targets. In the past decade, there has been increasing focus on the possible connection between increased intestinal mucosal permeability, inflammation, and visceral hypersensitivity. Increased permeability in subsets of IBS patients has been observed and the possible mechanisms underlying this defect are just beginning to be understood. The objectives of this review are: to summarize the role of the healthy intestinal epithelium as a barrier between the lumen and the rest of the body with a focus on tight junctions; to examine the lines of evidence which suggest that different triggers lead to increased intestinal mucosal permeability and disruption of tight junctions in IBS patients; and to explore how this increased permeability may elicit immune responses which affect afferent nerves, resulting in the pain associated with IBS.
PMID: 22837345 [PubMed - as supplied by publisher]View the full article