Migrating Motor Complex has been implicated with SIBO. Most gas-producing bacteria live in the colon, but in SIBO there are large quantities in the small intestine. Hydrogen and methane are the by-products of these bacteria, which can cause constipation and diarrhea respectively. IBS patients are typically methane or hydrogen producers. Methane slows intestinal peristalsis, while hydrogen speeds it up. Motility problems in the small intestine can lead to SIBO. The symptoms for both SIBO and IBS seem to be identical.
SIBO is thought to occur because of a deficiency in the Migrating Motor Complex (MMC). Migrating Motor Complex is a process of the small intestine. It is a cleansing wave that moves matter, including bacteria, from the small intestine and into the colon. This occurs every 90 to 120 minutes and only during fasting. The process is interrupted by feeding. A decrease in MMC is thought to be the major factor in IBS / SIBO.
Digestive processes of the stomach and small intestine can be digestive and interdigestive. The interdigestive state happens after digestion, 2 or 3 hours after a meal. The MMC starts in the stomach and works its way to the ilium (between small and large intestine). This peristaltic actions sweeps the lumen (the space inside the intestine) clean as it advances. MMC occurs during consciousness and sleep. It takes up to 2 hours for the MMC peristalsis to move from stomach to ilium. The time lapse between cycles is longer during the day than night.
These peristaltic cycles continue until food is eaten. Food in the upper digestive tract stops this motion in its tracks.
MMC and digestive motility are both mediated by the enteric nervous system. MMC seems largely responsible for clearing indigestible food particles from the stomach and plays a pivotal role in ridding bacteria from the small intestine.
MMC complements digestive motility. When food is present, digestive motility is "switched on" and takes over from MMC. The digestive motility is called segmentation as food is moved backwards and forwards in the intestine and mixing of enzymes and mucus occurs. These are peristaltic, circular smooth muscle movements that prevent food moving back into the mouth while longitudinal contractions move the food forward towards the colon.
https://www.inkling.com/read/medical-physiology-rodney-rhoades-david-bell-4th/chapter-25/small-intestinal-motility
Diet is an important control for SIBO / IBS. The gas from bacteria is caused by fermentation of undigested carbohydrates, namely high FODMAP vegetables and grains, starches and soluble fibre. Reducing these foods will help to starve off the microbes.
Anything that retards efficient digestion may result in SIBO / IBS symptoms. An adequate fasting period is crucial and grazing on food throughout the day is discouraged as this impedes the MMC process. Meals should be kept to 3 a day with at least a space of 3 - 5hours between them, and the evening meal should be eaten as early as possible to allow a long, overnight fasting period.
Antibiotics may not work as a long-term cure as bacteria can repopulate after 2 weeks. Long term medication use isn't advised as drug resistance can easily develop. Medications are never designed as a long-term measure, and should only be used for short-term symptom relief.
SIBOinfo.com
http://www.siboinfo.com/prevention.html
Small Intestinal Bacterial Overgrowth - What to Do When Unwelcome Microbes Invade
http://www.todaysdietitian.com/newarchives/040511p46.shtml
Mechanism of Interdigestive Motor Migrating Complex
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400812/
The SIGO saga: part II
http://alt-ternativeautoimmune.com/2014/03/the-sibo-saga-part-2.html
Mechanism of Interdigestive Migrating Motor Complex
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400812/
Is the cyclic nature of the migrating motor complex dependent on the sleep cycle?
http://www.hon.ch/OESO/books/Vol_5_Eso_Junction/Articles/art014.html
Gastrointestinal Motility
http://humanbiology.wzw.tum.de/fileadmin/Bilder/tutorials/tutorial.pdf
Uninvited Guests: The impact of SIBO on nutritional status
http://www.medicine.virginia.edu/clinical/departments/medicine/divisions/digestive-health/nutrition-support-team/nutrition-articles/zaidelarticle.pdf
SIBO is thought to occur because of a deficiency in the Migrating Motor Complex (MMC). Migrating Motor Complex is a process of the small intestine. It is a cleansing wave that moves matter, including bacteria, from the small intestine and into the colon. This occurs every 90 to 120 minutes and only during fasting. The process is interrupted by feeding. A decrease in MMC is thought to be the major factor in IBS / SIBO.
Digestive processes of the stomach and small intestine can be digestive and interdigestive. The interdigestive state happens after digestion, 2 or 3 hours after a meal. The MMC starts in the stomach and works its way to the ilium (between small and large intestine). This peristaltic actions sweeps the lumen (the space inside the intestine) clean as it advances. MMC occurs during consciousness and sleep. It takes up to 2 hours for the MMC peristalsis to move from stomach to ilium. The time lapse between cycles is longer during the day than night.
These peristaltic cycles continue until food is eaten. Food in the upper digestive tract stops this motion in its tracks.
MMC and digestive motility are both mediated by the enteric nervous system. MMC seems largely responsible for clearing indigestible food particles from the stomach and plays a pivotal role in ridding bacteria from the small intestine.
MMC complements digestive motility. When food is present, digestive motility is "switched on" and takes over from MMC. The digestive motility is called segmentation as food is moved backwards and forwards in the intestine and mixing of enzymes and mucus occurs. These are peristaltic, circular smooth muscle movements that prevent food moving back into the mouth while longitudinal contractions move the food forward towards the colon.
https://www.inkling.com/read/medical-physiology-rodney-rhoades-david-bell-4th/chapter-25/small-intestinal-motility
Diet is an important control for SIBO / IBS. The gas from bacteria is caused by fermentation of undigested carbohydrates, namely high FODMAP vegetables and grains, starches and soluble fibre. Reducing these foods will help to starve off the microbes.
Anything that retards efficient digestion may result in SIBO / IBS symptoms. An adequate fasting period is crucial and grazing on food throughout the day is discouraged as this impedes the MMC process. Meals should be kept to 3 a day with at least a space of 3 - 5hours between them, and the evening meal should be eaten as early as possible to allow a long, overnight fasting period.
Antibiotics may not work as a long-term cure as bacteria can repopulate after 2 weeks. Long term medication use isn't advised as drug resistance can easily develop. Medications are never designed as a long-term measure, and should only be used for short-term symptom relief.
SIBOinfo.com
http://www.siboinfo.com/prevention.html
Small Intestinal Bacterial Overgrowth - What to Do When Unwelcome Microbes Invade
http://www.todaysdietitian.com/newarchives/040511p46.shtml
Mechanism of Interdigestive Motor Migrating Complex
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400812/
The SIGO saga: part II
http://alt-ternativeautoimmune.com/2014/03/the-sibo-saga-part-2.html
Mechanism of Interdigestive Migrating Motor Complex
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400812/
Is the cyclic nature of the migrating motor complex dependent on the sleep cycle?
http://www.hon.ch/OESO/books/Vol_5_Eso_Junction/Articles/art014.html
Gastrointestinal Motility
http://humanbiology.wzw.tum.de/fileadmin/Bilder/tutorials/tutorial.pdf
Uninvited Guests: The impact of SIBO on nutritional status
http://www.medicine.virginia.edu/clinical/departments/medicine/divisions/digestive-health/nutrition-support-team/nutrition-articles/zaidelarticle.pdf