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FDA accepts New Drug Application for Prucalopride for CIC


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#1 annie7

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Posted 30 March 2018 - 07:26 AM

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https://globenewswir...nstipation.html

 

 

thanks so much to one of our members, wgbutler, for posting this information  yesterday on the  "drugs against C in the pipeline"  thread. i thought i would start a topic on it  here just to help make sure everybody sees it.

 

this is such good news!  finally--it's about time!   prucalopride has been available in other countries for several years now. 

 

what makes prucalopride special is that it's a high affinity selective serotonin type 4 (5-HT4)  receptor agonist--a  prokinetic med that stimulates colonic peristalsis, increasing bowel motility.  it's much different than amitiza, linzess and trulance.   for those of us who remember zelnorm,  it's similar to zelnom, but with a better safety profile. 


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these are just my own thoughts. for expert medical advice please contact a health care professional.


#2 wigglesmom

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Posted 07 April 2018 - 08:20 AM

Does this mean it's available now? Looking like it might not be available until Dec. 2018, but hoping I am wrong. 



#3 annie7

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Posted 07 April 2018 - 08:47 AM

no, sorry--it's not available now.  it's  just been sent in for the fda to consider for approval.  it should be approved in december and then it will become available during the first part of   2019.   it's a long time to wait, i know.  i wish the fda would fast-track it, like they did with linzess.

 

if you can get your doc to write you a script for it, you can buy it online at one of the online canadian pharmacies, like canadapharmacyonline.com.    they have it but they need a script in order to send it to you.  i've read posts from people who have done this. here is one of  the threads on the ADMD  motility disorders support board about that

 

 

https://www.inspire....opride-for-cic/

 

and :

 

https://www.canadaph...ame=Resolor6820


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#4 wigglesmom

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Posted 08 April 2018 - 08:29 AM

Oh, thank you! I didn't know that. 



#5 annie7

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Posted 08 April 2018 - 12:11 PM

you're welcome--good luck with everything.


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#6 dac122

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Posted 18 July 2018 - 01:20 PM

I believe this drug is also available in Canada.  Those with Docs willing to write scripts to Canada could get it.  My last check showed it was expensive, well over $100 for 30 days supply.



#7 annie7

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Posted 18 July 2018 - 01:26 PM

yes, as i mentioned earlier,  in my second post, as long as you have a script for it,  you can get prucalopride from one of the online canadian pharmacies.    and yes, it's quite expensive.   you can check out that link i posted, where people discuss getting it from canada.


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#8 Zoltar

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Posted 05 November 2018 - 06:06 PM

Been available in the uk for ages, maybe couple of years. Linzess is more reliable for me personally, although i find prucalopride helps with trapped gas better.



#9 dac122

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Posted 14 November 2018 - 04:03 PM

Been available in the uk for ages, maybe couple of years. Linzess is more reliable for me personally, although i find prucalopride helps with trapped gas better.

 

I am waiting here in the US for prucalopride to hit the market and am wondering what to expect.  I think trapped gas is one of my problems. 

 

Can you speak to any side effects of prucalopride or other things we should know?



#10 joeyr2

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Posted 26 November 2018 - 11:43 AM

https://globenewswir...nstipation.html

 

 

thanks so much to one of our members, wgbutler, for posting this information  yesterday on the  "drugs against C in the pipeline"  thread. i thought i would start a topic on it  here just to help make sure everybody sees it.

 

this is such good news!  finally--it's about time!   prucalopride has been available in other countries for several years now. 

 

what makes prucalopride special is that it's a high affinity selective serotonin type 4 (5-HT4)  receptor agonist--a  prokinetic med that stimulates colonic peristalsis, increasing bowel motility.  it's much different than amitiza, linzess and trulance.   for those of us who remember zelnorm,  it's similar to zelnom, but with a better safety profile. 

@Annie7 Isn't a 5-HT4 receptor the same thing as linzess?  Does this stuff pull fluids into the intestines like the osmotic laxatives that are currently available?



#11 annie7

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Posted 26 November 2018 - 11:57 AM

no,  a 5-HT4 receptor agonist is not like linzess etc.  it's a prokinetic med that stimulates peristalsis thus increasing bowel motility.  it doesn't pull fluid into the colon like linzess, trulance, and amitiza do. 

 

 

https://www.ncbi.nlm...pubmed/20408739


these are just my own thoughts. for expert medical advice please contact a health care professional.


#12 Vince Brazil

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Posted 13 December 2018 - 09:44 AM

Here in Brazil is avaliable pharma-grade. 



#13 wgbutler

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Posted 17 December 2018 - 09:47 AM

BOOM!

Apparently it's going to be called "Motegrity" in the United States.  Kind of a weird name.  I liked the name "Resolor" better, but whatever.

https://www.ptcommun...-adults-chronic

 

https://globenewswir...pation-CIC.html

 

https://www.streetin...C/14927835.html

 

https://www.nasdaq.c...-20181217-00296


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#14 annie7

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Posted 17 December 2018 - 09:54 AM

thanks SO much for posting this wonderful news!!!!   Hooray!!!!!!!!!!!!!!!!!!!!!! 

 

(i wonder how that name--motegrity-- is pronounced????  )


these are just my own thoughts. for expert medical advice please contact a health care professional.


#15 wgbutler

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Posted 17 December 2018 - 10:16 AM

thanks SO much for posting this wonderful news!!!!   Hooray!!!!!!!!!!!!!!!!!!!!!! 

 

(i wonder how that name--motegrity-- is pronounced????  )

If I had to guess I'd think its pronounced in a similar way to the word "integrity", except with the syllable "mo" (rhyming with the word "row")  at the beginning.

Now bring on Zelnorm, Tenapanor, Elobixibat, and the vibrating capsule, and other things.

We need lots of different options for this horrible condition!



#16 annie7

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Posted 17 December 2018 - 02:37 PM

yes--thanks-- you're probably right on the pronounciation.    and yes, it sure is a weird name!  i liked "resolor" better, too.

 

and thanks for all your helpful links.

 

yes we sure do need a lot of options.   like you say--bring 'em on!


these are just my own thoughts. for expert medical advice please contact a health care professional.


#17 dac122

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Posted 17 December 2018 - 02:53 PM

(i wonder how that name--motegrity-- is pronounced????  )

 

I am sure we will know soon enough as we get bombarded with commercials about it being the only pro-motility agent, warm little mascots and happy patients enjoying the sunset, resuming an active lifestyle. laugh.png  


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#18 wgbutler

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Posted 17 December 2018 - 04:19 PM

 

I am sure we will know soon enough as we get bombarded with commercials about it being the only pro-motility agent, warm little mascots and happy patients enjoying the sunset, resuming an active lifestyle. laugh.png  

That's hilarious!  And you know that's exactly what is going to happen.  In reality, if these companies displayed realistic commercials, they would show people running back and forth to the bathroom with uncontrollable D for hours.  (But I realize that Motegrity/Prucalopride won't have this effect on most patients)

One time I took a Trulance pill and it actually did what these commercials say that these drugs do.  I had one massive, extremely relieving experience in the bathroom and then it was all over and I didn't have to go to the bathroom any more that day.  I was so amazed that I told the nurse practitioner at my GI's office about it when I saw her on my next GI appointment, and she remarked, "so that was just like the commercials!"

On another note, the constipation drug wars are about to begin:

https://www.fierceph...-drug-motegrity


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#19 dac122

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Posted 17 December 2018 - 04:42 PM

On another note, the constipation drug wars are about to begin:

https://www.fierceph...-drug-motegrity

 

May the safest, most effective drug with least side effects win!



#20 nikki-m

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Posted 18 December 2018 - 01:17 PM

I am so happy to hear about this - I am actually seeing my gastroenterologist tomorrow and I plan to speak with him about it.  I hope it becomes available soon! 







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