Opiates and IBS
Posted 11 January 2003 - 07:32 AM
Posted 11 January 2003 - 02:32 PM
Posted 13 January 2003 - 02:08 PM
Posted 13 January 2003 - 03:15 PM
Posted 13 January 2003 - 03:19 PM
If there's a problem I am licensed in the State of Tennessee.
I am also a poet and I suffer from IBS so sometimes my opinions come from there.
My opinions should be seen as no more correct than any other person's opinions who has IBS, like you.
Posted 13 January 2003 - 03:39 PM
Posted 13 January 2003 - 04:31 PM
Posted 13 January 2003 - 04:36 PM
Posted 13 January 2003 - 04:48 PM
Posted 13 January 2003 - 06:31 PM
Ph.D in Biology
Posted 13 January 2003 - 07:00 PM
Posted 13 January 2003 - 07:38 PM
Posted 14 January 2003 - 02:11 AM
Please make sure you have your symptoms diagnosed by a medical practitioner or a doctor.
Posted 14 January 2003 - 02:39 AM
Posted 14 January 2003 - 03:11 AM
The effects of opiates is complicated. Different parts of the gut are affected in different ways and there are multiple effects over time. Opiates increase and decrease gut motility in sequence, but that is even simplified because the effects are different depending on whether you are talking about the small intestine or the colon. It is probably reasonable to say as general as can be that opiates decrease peristalsis but at the same time can increase tone and increase segmenting contractions. As some people might like to put it, they cause spasms.In addition, loperamide decreases secretion and enhances absorption and this is primary reason drugs like these are used to treat diarrhea.As for pain, theoretically, it should increase pain threshold (meaning to reduce pain) because that effect begins in peripherally (along gut-brain axis) and not centrally (in the brain).As a result of this a drug called trimebutine (Modulon) was developed, which was supposed to target the pain and like loperamide, it does not cross the BBB. Fedotozine just mentioned also was supposed to do this, but apparently did not work out.quote:How does imodium differ in it's effect on the gut? Obviously doesn't stop pain, but that is only because it does not cross the blood brain barrier correct? Or no?
I�m not sure it has been studied whether loperamide would have this effect and to what degree.quote:If it's the nerves in the gut that are over sensitive, wouldn't imodium have the same bounce back effect?