When I started supplementing I was routinely almost falling asleep at the wheel (and certainly at my desk) in the afternoons, I had borderline high cholesterol for years, was hypertensive, borderline obese, had an arthritic hip that kept activity to less than an hour at a stretch, had a 10 year history of daily IBS-D, and 30 years of indigestion that had finally become an all day long, chronic burning and was developing into nighttime reflux. I had a 30 year history of smoking--now 15 years in my past--and fatty diets, drank too much, had passed some gall bladder stones and undergone one, non-specific gastric attack. I have an immediate family history of heart disease and diabetes II, along with colon cancer. In March of 1998 I started feeding high quality, highly absorbed vitamins and minerals into my system, added flavonoids and a glucosamine complex that summer, and have since added probiotics, plant phytosterols, omega 3s and broad spectrum antioxidants. These have worked alone and in concert to clear me of all of the chronic conditions, which allowed me to introduce a lower fat diet and consistent exercise to address my weight issues and my blood pressure. (A combination of the minerals is claimed in the patent materials to help with the control of blood sugar, which may be one reason why my mother had d2 and my brother currently has it and I don't.)When I started down this path I felt like hell and did not think I was going to live much longer. Over 13 years later, I am 66 and feel in the peak of health. I really do believe this is possible for most people if they choose to treat their wellness rather than their sickness; but you have to make that choice, your doctor is not going to suggest it.Mark