I can't say the Amitiza has made a huge difference by itself but here is where I was and what I did: about 2 months ago I cut out eating Hershey's unsweetened chocolate because it's high in oxalates and now I have kidney stones.
That led to serious C. I thought I was developing tolerance to zelmac and considered taking a holiday from it, but was too scared of getting even worse C. Some of my symptoms (nausea) made me think I was having partial obstructions that resolved by themselves. So I was getting very scared. I was taking a high dose calcium channel blocker (verapamil) so I cut that in half, which helped for a week or so but then I started getting bogged down again. So I added 8 mg amitiza b.i.d. with food, leaving everything else the same (still taking zelmac). Those are all the changes I made to my regimen, and since starting the Amitiza I've had no problems at all, I'm going normally every day and even the trapped gas is as manageable as it was when I first started zelnorm.So I think but am not 100% certain that I've had a positive result from amitiza. To be sure I would need to stop it, but better not to change what's not broke!BTW the 24 mg amitiza was a DISASTER for me: nausea, bloating, gas, feeling generally terrible. 8 mg is a whole different experience.