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drugs against C in the pipeline--with updates


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#1 Nuffa

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Posted 12 February 2015 - 02:04 AM

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I keep on searching the net for any news. I know there are one or two drugs in the pipeline but can't find any further information. Can someone provide me with links/information?

#2 annie7

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Posted 12 February 2015 - 05:32 AM

i don't know what's in the pipeline in germany, where you are. with the exception of the vibrating capsule, the following are in the usa pipeline,   just google for more links and info on these---lots of info online.    

 

           

that vibrating capsule in development in israel  (not in usa pipeline AFAIK) :

 

       http://www.usatoday....apsule/8513473/

 

            

          http://www.vibrantga...index.php?pid=3

 

 

velusetrag  

 

      http://www.theravanc...astrointestinal

 

       http://en.wikipedia....wiki/Velusetrag

 

elobixibat

 

      http://www.iffgd.org...news/elobixibat

 

     http://www.ncbi.nlm....les/PMC4107709/

 

 

     http://adisinsight.s...drugs/800029037

 

plecanatide

 

     http://www.synergyph...ine/plecanatide

 

 

tenapanor

 

 

     http://www.prnewswir...-277714701.html

 

 

 

     http://www.ncbi.nlm....pubmed/26065434

 

     

     

 

relamorelin

 

 

    http://www.prnewswir...-719659361.html

 

SYN-010

 

       http://www.synthetic...me-Detailed-at-

Companys-Investor-Day

 

  http://www.synthetic...ipeline/syn-010

 

...and i'm still hoping prucalopride is in the usa pipeline somewhere...

 

 

hopefully someone else can add to this.  i don't have a lot of time to dig around right now..maybe later.


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these are just my own thoughts. for expert medical advice please contact a health care professional.


#3 flossy

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Posted 13 February 2015 - 03:40 AM

i don't know what's in the pipeline in germany, where you are. with the exception of the vibrating capsule, the following are in the usa pipeline,   just google for more links and info on these---lots of info online.    

 

that vibrating capsule in development in israel  (not in usa pipeline AFAIK) :

 

       http://www.usatoday....apsule/8513473/

 

 Vibrating capsules?!? I could just see when it passes my prostrate, and me having having multi-orgasms, all while doing something like praying in church.

 

"What's that?!?"

 

"Ut-oh!" (Hey-now!) lol!!! 

 



#4 annie7

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Posted 13 February 2015 - 05:48 AM

oh Flossy--too funny!  biggrin.png

 

right after the news of this magic pill came out last year, steven colbert had a wildly funny sketch on his show about it.  he called this his "number one story--or raher number "two story" that night and he advised  that rather than use this pill, just put your cell phone on vibrate and put it up your butt lol and then call yourself....gives new meaning to the phrase "the call to stool"....

 

his sketch is in this show, right after the beginning (one minute 12 seconds into it)    biggrin.png

 

 

               http://thecolbertrep...nstipation-pill


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#5 Nuffa

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Posted 15 February 2015 - 11:33 AM

Thanks very much annie.i am currently trying the resolor. Helps, but it isn't the final solution for me. I keep on trying until i find a solution. How do you say annie? Hope springs eternal!!!

#6 annie7

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Posted 15 February 2015 - 02:28 PM

glad you are trying resolor and that it's helping a little but sorry it isn't the whole solution for you.  if you're taking the 1 mg, try  2 mg dose.

 

I've read some people take resolor with miralax (movicol) or some other osmotic laxative or a stool softener or even magnesium (tablets or natural calm etc)  and it works better for them that way.  the osmotic helps soften things up and the resolor pushes it out.

 

I've also heard a few people say that resolor can take two or three weeks to get into your system and start to work fully...but, then, we're all so different in how meds work on us..

 

yes, it's a lot of experimentation and trial and error, isn't it.  and oh yes--hope springs eternal!   if it wasn't for hope--and faith--i'd have nothing.  keeps me going.  smile.png

 

keeping you in my prayers!


these are just my own thoughts. for expert medical advice please contact a health care professional.


#7 annie7

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Posted 02 May 2015 - 05:24 AM

i'm going to try to keep this thread up-to-date and (thanks to kc99 for the information!) adding another med currently in the pipeline:

 

YKP10811--a serotonin 5 HT 4 receptor agonist

 

      

    http://www.healio.co...al-constipation

 

 

    http://www.ncbi.nlm....pubmed/25148765

 

 

 

also--the vibrant capsule is now in clinical trails in the usa

 

     https://clinicaltria...how/NCT02030756


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#8 Nuffa

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Posted 03 May 2015 - 08:50 AM

Thanks so much annie!

#9 annie7

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Posted 03 May 2015 - 09:18 AM

thanks for starting this topic, Nuffa smile.png .  it's a good one to have on the board.


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#10 annie7

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Posted 05 August 2015 - 09:39 AM

update on plecanatide. updated 6/2016

 

it's in phase 3 of the clinical trials now.  synergy pharma filed an NDA for plecanatide  in january 2016.  if approved, they plan to launch it in 2017.

 

          

 

     http://www.healio.co...ic-constipation

 

 

 

     http://www.synergyph...ent/plecanatide

 

 

 

      http://www.businessw...anatide-Chronic


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#11 annie7

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Posted 28 September 2016 - 10:04 AM

update on plecanatide:

 

     http://www.streetins...g/12078875.html


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#12 Nuffa

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Posted 28 September 2016 - 12:54 PM

Thanks Annie!

#13 annie7

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Posted 28 September 2016 - 01:56 PM

thanks for starting this thread, Nuffa--great idea!  smile.png


these are just my own thoughts. for expert medical advice please contact a health care professional.


#14 annie7

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Posted 11 October 2016 - 07:50 AM

update on SYN-010

 

 

http://www.healio.co...ing-fda-meeting

 

 

http://www.synthetic...ipeline/syn-010


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#15 annie7

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Posted 21 October 2016 - 07:21 AM

   update on tenapanor for IBS-C :

 

 

   http://www.medpageto...203337d0r&pos=1

 

   http://awomanshealth...bowel-syndrome/


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#16 Nuffa

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Posted 15 December 2016 - 02:44 AM

Update on plecanatide ( sp?) it's coming soon. http://www.empr.com/...article/578340/
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#17 annie7

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Posted 15 December 2016 - 06:05 AM

thanks, Nuffa!  this drug  sounds very promising.  there's always hope!  smile.png


these are just my own thoughts. for expert medical advice please contact a health care professional.


#18 annie7

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Posted 26 December 2016 - 08:46 AM

linzess news:

 

a new and supposedly better formula of linaclotide (linzess) is in the pipeline--linaclotide colonic release-1  (CR1).  looks like it's supposed to be better for abdominal pain relief.

 

   http://www.allergan....e-phase-iib-(1)

 

 

    http://www.bizjourna...ve-data-on.html

 

 

also -- a new low dose 72 mcg form of linzess:

 

   http://globalpharmau...c-constipation/


these are just my own thoughts. for expert medical advice please contact a health care professional.


#19 annie7

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Posted 20 January 2017 - 08:33 AM

plecanatide  (trulance)  has been approved!

 

 

 

             http://www.ibsgroup....-been-approved/


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#20 flossy

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Posted 21 January 2017 - 09:07 AM

I can't wait to see if people like it or not.


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