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[Nuffa]

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I keep on searching the net for any news. I know there are one or two drugs in the pipeline but can't find any further information. Can someone provide me with links/information?

[annie7]

i don't know what's in the pipeline in germany, where you are. with the exception of the vibrating capsule, the following are in the usa pipeline,   just google for more links and info on these---lots of info online.    

 

           

that vibrating capsule in development in israel  (not in usa pipeline AFAIK) :

 

       http://www.usatoday....apsule/8513473/

 

            

          http://www.vibrantga...index.php?pid=3

 

 

velusetrag  

 

      http://www.theravanc...astrointestinal

 

       http://en.wikipedia....wiki/Velusetrag

 

elobixibat

 

      http://www.iffgd.org...news/elobixibat

 

     http://www.ncbi.nlm....les/PMC4107709/

 

 

     http://adisinsight.s...drugs/800029037

 

plecanatide

 

     http://www.synergyph...ine/plecanatide

 

 

tenapanor

 

 

     http://www.prnewswir...-277714701.html

 

 

 

     http://www.ncbi.nlm....pubmed/26065434

 

     

     

 

relamorelin

 

 

    http://www.prnewswir...-719659361.html

 

SYN-010

 

       http://www.synthetic...me-Detailed-at-

Companys-Investor-Day

 

  http://www.synthetic...ipeline/syn-010

 

...and i'm still hoping prucalopride is in the usa pipeline somewhere...

 

 

hopefully someone else can add to this.  i don't have a lot of time to dig around right now..maybe later.

[flossy]

i don't know what's in the pipeline in germany, where you are. with the exception of the vibrating capsule, the following are in the usa pipeline,   just google for more links and info on these---lots of info online.    

 

that vibrating capsule in development in israel  (not in usa pipeline AFAIK) :

 

       http://www.usatoday....apsule/8513473/

 

 Vibrating capsules?!? I could just see when it passes my prostrate, and me having having multi-orgasms, all while doing something like praying in church.

 

"What's that?!?"

 

"Ut-oh!" (Hey-now!) lol!!! 

 

[annie7]

oh Flossy--too funny!  

 

right after the news of this magic pill came out last year, steven colbert had a wildly funny sketch on his show about it.  he called this his "number one story--or raher number "two story" that night and he advised  that rather than use this pill, just put your cell phone on vibrate and put it up your butt lol and then call yourself....gives new meaning to the phrase "the call to stool"....

 

his sketch is in this show, right after the beginning (one minute 12 seconds into it)    

 

 

               http://thecolbertrep...nstipation-pill

[Nuffa]

Thanks very much annie.i am currently trying the resolor. Helps, but it isn't the final solution for me. I keep on trying until i find a solution. How do you say annie? Hope springs eternal!!!

[annie7]

glad you are trying resolor and that it's helping a little but sorry it isn't the whole solution for you.  if you're taking the 1 mg, try  2 mg dose.

 

I've read some people take resolor with miralax (movicol) or some other osmotic laxative or a stool softener or even magnesium (tablets or natural calm etc)  and it works better for them that way.  the osmotic helps soften things up and the resolor pushes it out.

 

I've also heard a few people say that resolor can take two or three weeks to get into your system and start to work fully...but, then, we're all so different in how meds work on us..

 

yes, it's a lot of experimentation and trial and error, isn't it.  and oh yes--hope springs eternal!   if it wasn't for hope--and faith--i'd have nothing.  keeps me going. 

 

keeping you in my prayers!

[annie7]

i'm going to try to keep this thread up-to-date and (thanks to kc99 for the information!) adding another med currently in the pipeline:

 

YKP10811--a serotonin 5 HT 4 receptor agonist

 

      

    http://www.healio.co...al-constipation

 

 

    http://www.ncbi.nlm....pubmed/25148765

 

 

 

also--the vibrant capsule is now in clinical trails in the usa

 

     https://clinicaltria...how/NCT02030756

[Nuffa]

Thanks so much annie!

[annie7]

thanks for starting this topic, Nuffa  .  it's a good one to have on the board.

[annie7]

update on plecanatide. updated 6/2016

 

it's in phase 3 of the clinical trials now.  synergy pharma filed an NDA for plecanatide  in january 2016.  if approved, they plan to launch it in 2017.

 

          

 

     http://www.healio.co...ic-constipation

 

 

 

     http://www.synergyph...ent/plecanatide

 

 

 

      http://www.businessw...anatide-Chronic

[annie7]

update on plecanatide:

 

     http://www.streetins...g/12078875.html

[Nuffa]

Thanks Annie!

[annie7]

thanks for starting this thread, Nuffa--great idea!  

[annie7]

update on SYN-010

 

 

http://www.healio.co...ing-fda-meeting

 

 

http://www.synthetic...ipeline/syn-010

[annie7]

   update on tenapanor for IBS-C :

 

 

   http://www.medpageto...203337d0r&pos=1

 

   http://awomanshealth...bowel-syndrome/

[Nuffa]

Update on plecanatide ( sp?) it's coming soon. http://www.empr.com/...article/578340/

[annie7]

thanks, Nuffa!  this drug  sounds very promising.  there's always hope!  

[annie7]

linzess news:

 

a new and supposedly better formula of linaclotide (linzess) is in the pipeline--linaclotide colonic release-1  (CR1).  looks like it's supposed to be better for abdominal pain relief.

 

   http://www.allergan....e-phase-iib-(1)

 

 

    http://www.bizjourna...ve-data-on.html

 

 

also -- a new low dose 72 mcg form of linzess:

 

   http://globalpharmau...c-constipation/

[annie7]

plecanatide  (trulance)  has been approved!

 

 

 

             http://www.ibsgroup....-been-approved/

[flossy]

I can't wait to see if people like it or not.