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drugs against C in the pipeline--with updates


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#21 annie7

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Posted 27 January 2017 - 04:50 PM

the new, lower dose of linzess--72mcg--has been approved by the FDA and should be available the first quarter of this year.

 

      http://www.medscape....pal&uac=15603EK


these are just my own thoughts. for expert medical advice please contact a health care professional.


#22 annie7

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Posted 23 March 2017 - 12:55 PM

Trulance has just become available although not all pharmacies have it in yet.  

 

the synergy pharma reps will also be distributing free one week sample packs to gastroenterologists for their patients to try. 

 

there is a savings coupon for Trulance on the synergy website.

 

          https://www.trulance...CFR2Hswod6fYBlA


these are just my own thoughts. for expert medical advice please contact a health care professional.


#23 annie7

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Posted 25 April 2017 - 03:22 PM

update on tenapanor:  

 

 

     http://www.healio.co...mptoms-in-ibs-c


these are just my own thoughts. for expert medical advice please contact a health care professional.


#24 annie7

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Posted 01 July 2017 - 04:05 PM

update on SYN -010

 

 

 

 http://www.prnewswir...-300480127.html


these are just my own thoughts. for expert medical advice please contact a health care professional.


#25 annie7

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Posted 27 August 2017 - 04:10 PM

  update on elobixibat

 

 

https://globenewswir...t-in-Japan.html

 

 

 

wish they submit an nda for it here in the usa....


these are just my own thoughts. for expert medical advice please contact a health care professional.


#26 annie7

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Posted 14 October 2017 - 01:39 PM

update on tenapanor.  looks like  ardelyx will be submitting a new drug application for it with the fda in the second half of 2018.

 

 

 

https://www.healio.c...tal-ibs-c-trial

 

 

 

tenapor helps reduce abdominal pain and visceral hypersensitivity as well as help with C. 

 

 

https://www.streetin...g/13390753.html


these are just my own thoughts. for expert medical advice please contact a health care professional.


#27 annie7

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Posted 03 January 2018 - 02:39 PM

update on tenapor.

 

ardelyx plans on submitting a new drug application to the fda during the second half of 2018.

 

 

 

  https://www.prnewswi...-300576499.html


these are just my own thoughts. for expert medical advice please contact a health care professional.


#28 wgbutler

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Posted 28 March 2018 - 05:52 PM

Update on Prucalopride (Resolor)
 

https://globenewswir...nstipation.html
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#29 annie7

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Posted 28 March 2018 - 07:01 PM

thanks so much for posting this!  that's wonderful news!  Finally!!


these are just my own thoughts. for expert medical advice please contact a health care professional.


#30 stefan00790

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Posted 03 April 2018 - 09:58 PM

Hey annie7 ,  is Fortrans powder for bowel preparation same thing as Miralax just a quick thought from you .?



#31 annie7

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Posted 04 April 2018 - 07:33 AM

i don't know--i've never heard of it.    i googled it but google didn't tell me if it was the same as miralax or not.  it sounds similar,  but don't know if it's exactly the same.  it does sound like it has PEG in it --not sure if it's PEG 3350 like mirlalax--but it also has other stuff in it as well.  it sounds like it might be like GoLytly (has electrolytes in it).  that's my guess.


these are just my own thoughts. for expert medical advice please contact a health care professional.


#32 SpaceNeedle09

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Posted 19 April 2018 - 10:59 PM

Hey annie7 ,  is Fortrans powder for bowel preparation same thing as Miralax just a quick thought from you .?

 

Forlax is PEG 4000, a similar compound to Miralax PEG 3350.  (polyethylene glycol)

 I just ordered some PEG 4000 online, from a france based pharmacy. I dont tolerate Miralax/PEG 3350 well. I'm hoping PEG 4000 is better.

 

https://onlinelibrar...36.2003.01390.x

Comparison of efficacy and safety of two doses of two different polyethylene glycol‐based laxatives in the treatment of constipation



#33 annie7

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Posted 20 April 2018 - 07:12 AM

thanks for your information.  good luck with the PEG 4000. hope it works for you.  keep us posted. 


these are just my own thoughts. for expert medical advice please contact a health care professional.


#34 wgbutler

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Posted 06 September 2018 - 08:08 AM

Excellent news!  Synthetic Biologics has FINALLY partnered up with someone to do phase 2 testing of SYN-010.

 

This is the drug that suppresses the methane producing activity of archeobactors, which is a cause of chronic constipation in IBS-C patients.  Methane in the gut apparently slows down the transit of waste and the activity of the colon.  

 

There are no side effects to taking this drug.  No diarrhea, no abdominal pains, nothing.  If your chronic constipation is caused by methane producing bugs in the gut, all this will do is is impair their ability to create methane and essentially cure you.

 

https://seekingalpha...dr=1#email_link


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#35 annie7

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Posted 06 September 2018 - 08:15 AM

thanks so much for posting this!  wonderful news!


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these are just my own thoughts. for expert medical advice please contact a health care professional.


#36 wgbutler

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Posted 02 October 2018 - 06:56 PM

Tenapanor was submitted to the FDA for final approval on September 13, 2018 and should be available early next year.  It works by inhibiting the absorption of sodium in the gut, thereby increasing sodium levels in the large intestine and drawing more water into the large intestine.  In that respect the mechanism is similar to Linzess and Trulance.  Hopefully the side effects of diarrhea would be less severe.  I'm not sure how it compares, but there is only one way to find out.

 

https://www.prnewswi...-300711834.html


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#37 annie7

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Posted 03 October 2018 - 07:13 AM

thanks so much for posting this!  

 

yes, hopefully this med won't cause D like linzess and trulance can.


these are just my own thoughts. for expert medical advice please contact a health care professional.


#38 annie7

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Posted 20 October 2018 - 07:01 AM

zelnorm and prucalopride win fda panel's backing for constipation:

 

 

https://www.medpaget...lsyndrome/75810

 

 

hooray!!  this is huge.  finally we'll have not one but two C meds that increase peristalsis and motility--not like linzess, amitiza and trulance which only add fluid to the colon


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these are just my own thoughts. for expert medical advice please contact a health care professional.


#39 scrapdizzle21

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Posted 20 October 2018 - 10:13 AM

Any ideas how long til it could be available?

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#40 annie7

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Posted 20 October 2018 - 10:16 AM

so far i haven't read anything to indicate when zelnorm will be available.

 

according to this article, prucalopride should be approved by the fda around december 21.  and then hopefully it'll be available --if not by late december-- by january or february. 

 

 

https://globenewswir...nstipation.html

 

 

prucalopride is currently available in canada. if you can get your doc to write you a script for it, you can buy it from one of the canadian online pharmacies  like canada pharmacy online.com  it's quite expensive, though. 

 

 

 

 

https://www.canadaph...ame=Resolor6820


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these are just my own thoughts. for expert medical advice please contact a health care professional.






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