A Randomized Trial of 5-Hydroxytryptamine4-Receptor Agonist, YKP10811, on Colonic Transit and Bowel Function in Functional Constipation - IBS News, Media, Research Results, Discussion or Abstracts - IBS Self Help and Support Group Forums - IBSgroup.org
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A Randomized Trial of 5-Hydroxytryptamine4-Receptor Agonist, YKP10811, on Colonic Transit and Bowel Function in Functional Constipation


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#1 kc99

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Posted 01 May 2015 - 11:16 PM

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Another newer article -- found this one through the AGMD facebook page:

http://www.ncbi.nlm....pubmed/25148765

It's not open access, so, the full article will only be available to those with access to an institutional or individual subscription.

 

AGMD originally cited this news blurb:

 

http://www.healio.co...al-constipation

 

This all sounded good until I got to the quote saying that "YKP10811 is likely to be of benefit to patients with functional constipation without rectal evacuation disorders."   I hope they're just being careful to avoid making claims about patient groups that were excluded, and not ruling out the possiblity that this might help people with rectal evacuation disorders. 

 

 

 

 


  • annie7 likes this

#2 annie7

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Posted 02 May 2015 - 04:55 AM

Thanks, kc.

 

 it's good to know that there is finally a serotonin receptor agonist in the pipeline instead of all the prosecretory meds we've been seeing.  

 

i think they probably made that statement about evacuation disorders because, yes, patients with that problem were excluded--but also because it's so much more difficult for those of us with that problem--depending on the severity of it-- to get anything out at all or to fully evacuate even with the help of a medication.  in my case, zelnorm did not help me much although i thought it was better than nothing.

 

hopefully YKP10811 will make it through the pipeline fairly quickly.


  • kc99 likes this

these are just my own thoughts. for expert medical advice please contact a health care professional.






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