A Randomized Trial of 5-Hydroxytryptamine4-Receptor Agonist, YKP10811, on Colonic Transit and Bowel Function in Functional Constipation
Posted 01 May 2015 - 11:16 PM
Another newer article -- found this one through the AGMD facebook page:http://www.ncbi.nlm....pubmed/25148765
It's not open access, so, the full article will only be available to those with access to an institutional or individual subscription.
AGMD originally cited this news blurb:
This all sounded good until I got to the quote saying that "YKP10811 is likely to be of benefit to patients with functional constipation without rectal evacuation disorders." I hope they're just being careful to avoid making claims about patient groups that were excluded, and not ruling out the possiblity that this might help people with rectal evacuation disorders.
- annie7 likes this
Posted 02 May 2015 - 04:55 AM
it's good to know that there is finally a serotonin receptor agonist in the pipeline instead of all the prosecretory meds we've been seeing.
i think they probably made that statement about evacuation disorders because, yes, patients with that problem were excluded--but also because it's so much more difficult for those of us with that problem--depending on the severity of it-- to get anything out at all or to fully evacuate even with the help of a medication. in my case, zelnorm did not help me much although i thought it was better than nothing.
hopefully YKP10811 will make it through the pipeline fairly quickly.
- kc99 likes this
these are just my own thoughts. for expert medical advice please contact a health care professional.