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[tdhcsc]

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I was prescribed both by my gastrointerologist for my IBS-C.  She said I could take both if one doesn't help but try the Trulance first.  I looked around on the net and can't find anything about the difference.  They both do the same thing but last night I tried Motegrity and had relief in about 3 hours.  I woke up with a headache but it worked whereas the Trulance did nothing for the week I took it alone.

 

Trulance is called 'plecanatide' and is a 3mg tab while Motegrity is called 'prucalopride' and is 2mg.   At first I thought they might be the same with a name change but I guess that's not what happened and they are different medications.

 

Anyone know the difference?  I can't find anything on the net.

 

Dan

 

 

[annie7]

prucalopride (motegrity) is a prokinetic. it increases peristalsis. whereas trulance is not.  trulance works by adding fluid to the colon.

[tdhcsc]

So Trulance is much like Miralax?  I've been taking Miralax for a couple of years and recently had to start taking it twice a day which forced me to wear Depends.  Even at Miralax twice a day I had no joy of a BM at all, just brown water that I couldn't control. 

 

Hopefully the Motegrity will work for a while like it did last night.

[annie7]

yes, i hope motegrity keeps working for you, too.  

 

unfortunately headaches can be a side effect of motegrity but i've read that sometimes the headaches go away once your body becomes used to the drug.