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linaclotide
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  1. IBS Constipation (IBS-C) and Chronic Constipation
    Hi, has anyone encountered this or know why it would happen? After taking Linzess on Friday my kidneys were really sore this whole weekend, like someone had done a ton of kidney punches on me. The twist is that I had my right kidney successfully operated on for hydronephrosis a long while...
  2. IBS Constipation (IBS-C) and Chronic Constipation
    Hi, I'm trying Linzess 145mcg again but whilst it helps with the C, it's causing loads of abdominal pain. Unfortunately it's in a capsule which generally implies you can't split the dose. Is this the case? I tried taking every other day but it's still too strong. It seems that 145mcg in my...
  3. Research Studies
    A clinical study is being conducted at the University of Iowa Hospitals and Clinics evaluating the amount of linaclotide (Linzess) and its active metabolite that are present in breast milk. Women ages 18-45 who are actively breastfeeding and taking linaclotide (Linzess) for either...
  4. Constipation Prescription Medications
    Constella is now being marketed in Canada by Forest Laboratories. It is using the same name for the drug as in Europe. Product information is here: http://www.frx.ca/products.aspx
  5. IBS Constipation (IBS-C) and Chronic Constipation
    Hi, all I can find about its half-life is variations of which isn't very useful. Anyone care to take a punt at the half-life? I'm asking since 145mg / day causes loads of pain but does get my bowels moving. Therefore I'm planning to take it every other day (or even every x days). Thanks...
  6. IBS Constipation (IBS-C) and Chronic Constipation
    Hi, I can't find any references in the literature along the lines of "Linzess takes up to x weeks to start working" and after 2 weeks, I've just started feeling discernible differences. Is this likely/common? Unfortunately these changes are unpleasant so I'm wondering how long I should stick...
  7. IBS News, Media, Research, Discussion or Abstracts
    Almirall, S.A. (ALM:MC) and Ironwood Pharmaceuticals, Inc. (NASDAQ: IRWD) announced today that the European Commission has granted marketing authorization to Constella® (linaclotide 290mcg) for the symptomatic treatment of moderate to severe Irritable Bowel Syndrome with Constipation (IBS-C) in...
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