I've been lurking for quite some time, so I decided to register and offer my opinion. I was recently diagnosed with IBS after an exhausting round of tests. I'm sure you are familiar with them all. The GI was not the least bit interested in helping me with my discomfort, so I have turned to natural cures. In addition to a fiber drink (yuck) I use an herbal product called Iberogast. I have found this to be very helpful in times of severe distress.I suspect my IBS is mild compared to what many of you are describing, so this may not help you. If you are interested, the product is available at vitaminshoppe.com and probably other places.Here is a URL that describes the technical stuff: http://www.nat-med.com/archives/iberogast.htm Hope this helps..