I started out having luck with Viberzi, but the side effects are hard to handle. I can't stay awake. I also get pretty bad abdominal pains with it. Lately, I've been having what I would call re- bound diarrhea. It stops me up for awhile, but my body eventually needs to go and I get frequent diarrhea as the drug wears off. I have to be honest with you....if I only went twice a day I'd think I died and went to heaven. I sometimes have to go four or five time an hour when my IBS is really kicking in. As far as worrying about the bus trip, I would think Imodium would work just as good as Viberzi and you wouldn't need a prescription.