My name is Jack and I have had IBS-D all my life.(38) years. It has been a constant battle almost everyday. The only periods of some relief is when I restrict myself to just going to work and staying home. I have not gone away on vacation in over twenty years. The longest relationship I have ever been in was 5 months long. I just ended that one for the same reason that I ended all the previous ones. The stress of trying to maintain a relationship is just too much on my IBS. Being in a relationship brings with it the stress and anxiety of having to immediately increase your social interactions much faster than my IBS can handle. Bowing out of these social events or having to leave early due to a sudden episode of "D" is quite frustrating when the people you are with have no empathy. People think that all you have to do is just go to the bathroom once and relieve yourself and you are fine. They don't understand that I need a private bathroom to use and may need to make several trips. Sometimes after a few hours I still hurt as if someone is twisting my intestines like they are wringing out a wet dish rag.I have gained significant relief from the calcium supplements. Enough relief that I boldly agreed to go on a cruise to the Caribbean for a week with two close friends who understand my problem. At least if I can't participate in a lot of things or I am not feeling well, they can at least hang out together during those times. I went for a colonoscopy and all was ok. The doctor put me on Zoloft 50mg. Still waiting for it to kick in. I get anxiety and panic attacks due to the unpredictability of the IBS-D. I gained a lot of confidence due to the calcium supplements, but yesterday while we were at the travel agent I could feel the anxiety creeping in. I beat it down and signed up anyway. Although I am nervous about the trip, I have to see how I handle it. if it goes well, it will build my confidence. If it goes bad, well at least I tried before turning into a total recluse. Thanks for listening.