Some time ago I was taking Prozac with Wellbutrin to offset the negative sexual side effects of the Prozac. It didn't seem to help. A couple months ago I stopped the Prozac cause I was so tired of never "being in the mood". A week ago my Dr. put me on Wellbutrin, he said if taken by itself it should have no downside sexually and hopefully help with the depression. Since stopping the Prozac I've gained about 10 lbs. but seem to be more responsive with my partner. It's probably too soon to give the Wellbutrin any credit for that, but I really don't think it'll inhibit my sex drive like Prozac did.