Tom,The next drug being tested, which is currently on Phase III is Dexloxiglumide ... that's the closest one most likely to come out on the market, of course, subject to approval.The concept is very different to Zelnorm as it works on CCK (cholecystokinin). It's a hormone that is produced in the gut. It's supposed to reduce the pain one gets after consuming a meal and/or water, and helps with motility. I tried to get into the trials, but was turned down once they saw my medical records (stating "severe" IBS.) That too seems to be for mild to moderate cases, but who knows, it could work for us. I am not sure how far it is from being marketed or being approved, or how effective the trials have been. There hasnt been much feedback on the BB which isnt a good sign to me.Other than that there isn't anything in the pipeline for IBS C at this point. I know a web site that gives updates about all this. I'll try find it again in the morning and post it on this posting ... I'm too tired right now.By the way, how's Zelnorm going. I'm getting worse and worse. I've tried many ways of taking it ... closer to food, with food, 3 hours before, with a hot drink ... still not having any luck.I'm going to try it with strong coffee with caffeine (I hate coffee ... I'm a tea drinker and I dont like taking caffeine, however I will do anything to make this stuff work) Have you tried it with coffee yet? I'm starting probably on Wednesday, if I can get someone to buy me some ... its so tough being stuck at home and dependent on others ... and people wonder why I'm depressed!!Let us know if you find something that works. Good luck. Dont give up yet, please!!
Remember, were bigger than this stupid problem, we cannot let it beat us ... we have to be in control, not the illness