Douglas Garstang , just some more info, there are also 25 functional conditions that can overlap or where a person has symptoms that don't always fit into specific conditions, its possible about the CFAP ect and why the testing is so very important.The connection to the brain and the gut via endorphines and neurotransmitters is quite real and can be a source of problems or a contributing factor. http://www.med.unc.edu/medicine/fgidc/cfap.htm http://aboutibs.org/Publications/clinicalIssues.html http://www.med.unc.edu/medicine/fgidc/motility.htm These are some pet scans of IBS."Neuroimaging has provided evidence of physiological differences between normal individuals and those suffering from IBS in the way a visceral stimulus (ie, rectal distention) is processed in the brain.[14,15] Initial data from positron emission tomography (PET) scans demonstrated increased activation of the anterior cingulate cortex (ACC) among normal individuals, comparedto IBS patients. The ACC is a cerebral cortical area that is rich in opiate receptors and is thought to be a major component of cognitive circuits relating to perception as well as descending spinal pathways involving pain. More recently, fMRI was used to demonstrate increased activity in the ACC, prefrontal (PF), and insular cortex areas, and in the thalamus of IBS patients compared to normal individuals."