One non-drug approach that works for some people is Hypnotherapy or Cognitive Behavioral Therapy.CBT got rid of most of my over-response of the colon to eating (it is normal for it to increase in activity each time you eat).www.ibsaudioprogram.com is one set of tapes/CD's that has helped a lot of people here.Since the antispasmodic works, you might try peppermint on the same regime. A cup of peppermint tea or peppermint capsules (Altoids sometimes work for some people as the peppermint ones have a hefty dose of real peppermint oil in them) taken like that antispasmodic 20-30 minutes before a meal.Peppermint can relax the sphincter at the top of the stomach, so may bother people with Heartburn/GERD.K.