I've been on amitriptaline (elavil) for about a month and a half and have noticed some improvements with a 25mg a day dosage. The Ibs-d isn't gone completely, but i'm not as reactionary to foods, and my stools tend to be formed these days. My doc suggested upping the dosage to 35/40 mg a day and I tried it for a week. During that week I was hungrier than I've ever been (which I know is a side effect of the med) which made me eat more, larger meals and snacks. When I eat larger meals, or a lot in general, my IBS tends to act up. So, the upping of the dosage is not a good thing for me.I'm wondering if any of you tried both amitriptaline AND nortriptaline and whether or not you have noticed a difference between these medications. Or if you have tried some other tricilic which works for you. This is the only med which has proven somewhat useful for me (I've been on about 20 differnet routes with meds) which is quite inspiring, but it's still not a great fix.As everyone is, I'm just so fed up with this awful disorder and wish it would just leave my life.