I developed an anal fissure a couple of months ago. My GI doctor recommended a prescription cream of lidocaine and nifedipine. I hadn't taken it for long when I got the impression it was causing skin irritation, so I briefly stopped applying it. I started again and used it twice a day for a month or more. However, my skin throughout the anal-rectal area became very irritated and painful, so I stopped it again and haven't used it for about two weeks. I thought the fissure was beginning to heal and wondered if the medication not only caused irritation but didn't even work for me, but that improvement was short lived, and I feel like I'm back where I started in terms of the pain the fissure causes when I have bowel movements and a moderate level of pain and itching in the anal area. I can't decide whether the cream is causing the irritation or whether it's just my system and bowel habits. Sometimes they're kind of messy and I have to wipe a lot, so maybe it's the toilet paper causing the skin problems, or some tiny amounts of stool that remained despite my extensive cleaning. I've had IBS-C for 20 years and never had any skin irritation or itching like this, so it would seem that the fissure, and possibly the medication, are factors. But I can't decide whether I should restart the cream while being more vigilant about hygiene, or whether I should just keep on hoping the fissure will heal without use of medication. I sent an electronic message to my doctor and hope he'll be able to help me sort this out, and I'm also going to contact my dermatologist since this is a skin issue as well as a gastrointestinal problem. For others who have had fissures and used this cream, what was your experience?