I am posting this in the constipation forum because, well, that's what I have usually. I developed IBS-C when I was 15; I can even remember the day it began. At the same time, I developed anal fissures. I didn't know what they were when I was 15, but now, nearly 30 years later, after having gone the colorectal surgeon route, I know that the problem began at the same time the IBS began.I take Zelnorm, and it helps me a lot. Unfortunately though, it only seems to work for about 4 to 6 months at a time. After that, I have to go off of it for a while in order to have it work again. I know that beginning a new dose is going to work again because I will get a headache for 2 days after beginning the medication. If I don't get the headache, the Zelnorm isn't going to work.I have noticed something about the anal fissures, and I am wondering if anyone else has seen this. Zelnorm clears them up. I mean overnight. I had a particularly troublesome one that I was going to have to have cauterized again. I was on a Zelnorm holiday when the fissure began. I just started the Zelnorm again two days ago, and the fissure was gone over night. Does anyone know why Zelnorm would have this effect? Has anyone else seen Zelnorm do this? Thanks.Steven