Hi":I am in the process of weaning myself off of Effexor XR. It was tough in the beginning, but I stayed with it and the side effects went away except one--I gained nearly 20 lbs. If you read the side effects on the drug itself, weight gain is not one of them, but there are several sites out there where folks have reported a tremendous weight gain from it. Also, it did not help my "D" condition at all. Believe me, I sure do wish otherwise, because it did help my anxiety, etc., but this weight gain could not be. I am down to 37.5 mg. and have already lost two lbs. Just remember, I am telling you how it affected me, California 123 has had wonderful luck with it and I'm sure others have as well. We are all so different.Good luck!!!