If the flagyl doesn't seem to work, then I would find a doc that would order something like Nystatin or Diflucan (or some antifungal). Unfortunately, for some people it is a yeast problem. If she ever develops a vaginal yeast problem, it is almost a sure thing that this is what the problem may be. I had been on Amoxicillin for adult-oncet acne for over a year. Then I developed first a vag infection, and then a bladder infection. I have heard of some people getting the hives, but I was not one of them. She could have a med or perhaps developed someother type of allergy as sometimes the immune system goes a little haywire. None of my docs, GP, GI, or GU could figure it out. Even went so far as having a hyster and one ovary removed as they found endo and wondered if this could be the cause. The post surgical follow-up six wks. later found yeast caked to my vaginal wall. The antibiotic had masked the odor and symptoms of a usual infection. Unfortunately only a local/vaginal yeast treatment was given, and the painful stooling, cramping and bloating went on for a couple more years. It wasn't until I went to a good allergist who did some testing and found a big reaction to candida. This indicated that it was indeed a problem for me. A low sugar/low fermented diet (including staying away from citric acid which I was also found sensitive to and which is an additive made from fermented sugars), and the oral antifungal Diflucan gradually cleared up my symptoms. Unfortunately it went on for so long, it will take awhile for my system to balance itself again enough to go off the diet and antifungal. I also am taking antigen drops which I am not entirely sure are helpful or not, but the rest of it is working so I'm sticking with it for the three years they say it might take. You could begin by doing the diet and taking probiotics as suggested, (like a good refrigerated enteric coated kind), and seeing if this improves things.Good luck determining what the creature of the "deep" is and treating it effectively!M.