I am one of the rare persons that cannot tolerate SSRI antidepressants (4% of population)-causes agitation, racing thougths, insomnia, etc. Also tends to aggravate my C. Has anyone heard of an antidepressant that may not cause or aggravate C? I am very leary of trying anything new but am really in need of an antidepressant to get a hold on this funk I'm in. I've suffered off and on all my life with depression and have yet to find a medication that works without causing all kinds of other unpleasant side effects. Any suggestions would be appreciated. I am taking medication for anxiety which overall has helped some with the depression ( IBS) but I think at this point in my life I need something more intensive. My psychiatrist keeps saying there are "new drugs on the horizon" but who knows what that means-could be 10 years or more. Thanks, Tiss