I am taking Paxil for panic disorder, but it doesn't seem to help at all with the IBS. Several months ago I added klonapin, a tranquilizer, thinking it would help with the IBS, but it didn't help. A long time ago I was on amytriptylene, and it did seem to help some, but the side effects were pretty annoying. Has anyone come across a really good antidepressant that helps IBS? I guess there's been some studies done on the connection between anxiety and depression and IBS, but no-one really knows for sure which came first. I really think the IBS causes the depression and anxiety, not the other way around.I do remember, however, a time about thirty years ago, before I had bad IBS, when I did suffer from depression. My mom,though, has had IBS for years, not as bad as mine, but she never has suffered from depression. Anyway, I am really at my wits end trying to figure out how I should treat this......with antidepressants, food allergy testing, seeing a GI doctor, or what????Then of course there's prayer, and that sure can't hurt. I just don't know what to do.Please help if you can. (I've also had my thyroid tested and I have autoimmune thyroiditis, but not enough to require thyroid medication. The doctor did let me try it for awhile, though, and it made my panic disorder worse).Gerria