I took Lotronex for a very short period of time. It made me so constipated, I couldn't stand it. One of the very frustrating things about IBS is that no two people react the same way to meds and other therapies. You have to find what works best for YOU. And yes, that means some trial and error. But it will be well worth the effort in the long run. If you are uncomfortable taking an antidepressant, then talk to your doctor about other treatments. Maybe that should be a last resort for you.I do take Paxil and it has helped me tremendously. I have been able to get off of it for periods of time also, so it is not addicting. But talk with your doctor. And if your doctor won't listen to you, find a new one that will.