Dear Fellow-sufferers - My gastro doc in Boston has put me on a low dose of Prozac for IBS-D. He says it takes 3 weeks to really kick in and that it has really helped a couple of his patients. My problem is not being able to get rid of all stuff at one time, so that dribs and drabs are having to come out all day long.. plus a lot of lower gas, not to mention loss of appetite, nausea at times and.... well, you know, you've been there. Has Prozac helped any of you? Thanks, Libby