Yeah well I've exhausted all options and have come to the conclusion that Zelnorm was the onlyh effective treatmen for IBS-C. So I'm wondering there has to be some group of chemists and scientists who would like to capitalize on the thousands of people who now have no medications similar to Zelnrom to try. Has anyone heard of anything like this, or maybe even heard anything about the Zelnrom manufacturer's making some changes to the drug and then putting it back on the market??? Thanks to all and good luck!