I was on elavil for my ibs, but quite honestly that did nothing whatsoever, so my doc took me off it. Recently, I was put on Zoloft for mild depression/anxiety (which was caused by the IBS...a vicious cycle, this IBS and Depression). ZOloft has worked absolute wonders on me. I used to think it was normal to always feel sorry for myself and wonder why me and cry all the time. I never wanted to do anything, and I always stayed home. Now I know that's not normal, and Zoloft is helping me to live my life. Yea, I sometimes get down, and I pity myself, but it doesnt last long. In all honesty, I don't know where I'd be now without Zoloft.Hope that helps, at least a little.