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atrain,I tried it and it didn't have any effect at all. Tried all the other stuff like neostigmine, colchicine and Zelmac ... I don't think any will work for very severe cases. If your case isn't too severe, it could possibly help ... so it's worth giving it a try. There are some pretty dangerous side-effects though, especially with colchicine, so please be careful.Good luck and let us know how you are doing if you try any of the above meds.
 

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My doctor prescribed it for me about two years ago. I took it for six weeks with no improvement in my chronic constipation.
 
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