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I have tried taking Pentesa before which I guess is the same drug except its released into the small intestine whereas Asacol is realeased into the large intestine/colon with negative results and was thinking of trying Asacol. I had some tests done a few months back that showed that my IGA levels are deficient which suggest immuno issues. I know Asacol is prescribed for Crohn's and Colitis which are thought to be immune system disease's. Has anyone else tried taking this for their IBS?