Hi I am new to this board. I have been suffering w/IBS for about 10 years on and off.Have tried about 3 different meds. Lotronex worked the best but my doc took me off that about 2 yrs ago. I am currently taking a new otcdrug called Culturelle which is really working for me! They are about $22.00 for a 30 day supply. Off course I never ever leave my house w/o my immodium just in case. Please let me know if anyone has tried. Hoping this will help at least one person w/IBS.