Loraine,It took me about 4 to 6 weeks to get settled into the Lotronex. Initially I actually had cramps from it, and I thought I was getting headaches too. I got discouraged and was about to quit, when I picked up a thread on this BB from someone who had the same problems as I was having. He had toughed it out, hung in, and was settled into a dose with only occasional headaches and cramps. That has been my experience since, and I cut the evening dose because I wondered if I was getting some insomnia from the Lotronex. That dose has been like a miracle for me. Most of the time I'm not aware of my gut, which used to rumble and grumble even if I wasn't having a D attack. Now I rarely think about my stomach or bowels except when under extreme stress or if I do something too dumb with my diet (chili, beer or other heavy stuff.) In stress situations, I sometimes need Imodium or Lomotil, but I have cut the use of them to once or twice a month from my previous level of three or four times a week.Good luck. Give it a good try.Joe