I am 38 years old and female, I have had IBS for 9 years now. My doctor has put me on some different medications, most recently Lotronex about 3 weeks ago. I have cronic "D" about 6 movements aday with the pain and bloating that comes with it. Ever since I started the Lotronex it seems to have helped greatly. I had to cut my dosage due to constipation. I take a half a pill aday. I still get a little pain in my stomach but not so bad and not all the time. I was wondering if anyone has ever tried this? I know there is alot of different feelings about this medication, but you need to stay in tune with your body, if you have constipation as you main IBS symptom then you DON'T want to try Lotronex...thanks