yes that would be great to hear from someone who has tried prucalopride.prucalopride acts on serotonin receptors.this info on prucalopride is from the movetis website:In contrast to laxatives, prucalopride triggers a physiological and peristaltic reflex in the colon through stimulation of the 5HT4-receptors on the intramural nerves. This accelerates overall transit along the GI tract, induces colonic mass movement and significantly enhances colonic emptying. Prucalopride stimulates bowel function by specifically targeting the underlying impaired motility. http://www.movetis.com/journalists/press-r...urce=journalistif that link isn't clickable (it's awfully long) just go to the movetis website and look under "press releases" for more info on prucalopride.