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FYIDoes Bacterial Overgrowth Play a Role in IBS?Bacterial Overgrowth & IBS: Too Soon To TellBy Philip Schoenfeld, MD, MSEd, MSc (Epi)Associate Professor of Medicine, University of Michigan School of Medicine Chief, Division of Gastroenterology, VA Ann Arbor Healthcare System http://www.gastro.org/wmspage.cfm?parm1=1703
 

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The above article talks about Post Infectious IBS.Dr Spiller is a recognized leading expert on PI IBS and this is an up to date Paper on PI IBS.This is medscape and you have to register but its free. Its an excellent update"From Current Opinion in GastroenterologyPost-infectious Irritable Bowel SyndromePosted 12/08/2005Robin Spiller; Eugene Campbell Clinical FeaturesImportance of Psychiatric FeaturesRole of SerotoninRole of Inflammatory CytokinesRole of Mast CellsEvidence of Chronic Inflammation in Irritable Bowel SyndromeAnimal Models of Post-infective Irritable Bowel SyndromeAnti-inflammatory Effect of ProbioticsAnti-inflammatory Treatments in Irritable Bowel SyndromeConclusion--------------------------------------------------------------------------------Abstract and IntroductionAbstractPurpose of Review: Irritable bowel syndrome patients form a heterogeneous group with a variable contribution of central and peripheral components. The peripheral component is prominent in irritable bowel syndrome developing after infection (post-infectious irritable bowel syndrome) and this has proved a profitable area of research.Recent Findings: Recent studies have overthrown the dogma that irritable bowel syndrome is characterized by no abnormality of structure by demonstrating low-grade lymphocytic infiltration in the gut mucosa, increased permeability and increases in other inflammatory components including enterochromaffin and mast cells. Furthermore, increased inflammatory cytokines in both mucosa and blood have been demonstrated in irritable bowel syndrome. While steroid treatment has proved ineffective, preliminary studies with probiotics exerting an anti-inflammatory effect have shown benefit.Summary: The study of post-infectious irritable bowel syndrome has revealed the importance of low-grade inflammation in causing irritable bowel syndrome symptoms. It has suggested novel approaches to irritable bowel syndrome including studies of serotonin and histamine metabolism which may be relevant to other subtypes of of the disease."http://www.medscape.com/viewarticle/518355?src=mp
 
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