I use Donatel (belladonna is in its chemical name) only when I feel an attack coming on, and I use just a half-tab with a meal when I'm dining out to ward off discomfort that hits about 2 a.m. Even when picking low-fat stuff on a menu, other irritants can cause a flare-up, so as a precaution I find it works well at a half-dose. I'm a G type, with cramping and bloating as the problem, not excessive amt. I figured out my prob after a meal at KFC landed me in the hospital. I don't use it frequently enough to say if I've had side-effects. Now, back to the natural options reading! Ginger root, ginseng tea, peppermint tea and Altoids are on my to-try list.