I've been on this twice...many years ago, and just recently family doc said to try it again.She said OK to take it with my anti-anxiety drug(even though PDR says be careful) and good old immodium.Also because I had a really bad spell..she wanted me on it 4 times a day (20mg) no matter what. And she said to try it for one month, then let her know.It made me feel wierd,(a mixture of hyper and disoriented) and I had 2 more bad D spells during the week I was taking it. (She couldn't find a record of why I stopped taking it before...maybe specialist never gave her notes)And frankly I couldn't remember either...I've tried so many things!I gave it 8 days, then stopped taking it. Guess I will be going back to the GI doc soon. Anybody else have experience with this drug?Thanks