Does anyone have any recommendations for calming your colon? My doctor has me on Donnatal now, but it doesn't seem to make any difference. Because I cannot predict when my intestines are going to go into a spasm, (no telepathy here), I was taking the Donnatal once a day. Once the spasms start, it can get very painful, wearing me out, and I have no energy after the attacks. I seem to be experiencing these painful spasms more frequently this past year. It's usually followed by diarrhea. i have been diagnosed with IBS. Any suggestions for anti-spasmodics? Would low doses of an anti-depressant help? (I don't have depression, but it does get frustrating at times).