Hi. I have had IBS-D for 30 years. For the last 3 and a half years I had it completely under control by taking 2 Immodium in the AM and 2 Immodium with 2 Caltrate in the PM. Suddenly for no reason this regimen stopped working last Oct. I thought it would kick in again, but it did not. I started looking for other solutions and found Align. I have only just started it and wanted to know if there was any problem taking both Align and Caltrate. After reading this board I started by taking half a Caltrate and breakfast and lunch to today and plan to work up slowly.