I've read tons and tons of stuff lately about menopause, perimenopause and drugs that help with these issues. You are correct in your assumption that they can mess with your mind. It's amazing how much these hormones can effect your mind. In a basic sense, they can cause you to have PMS symptoms such as mood swings, bloating etc. Pretty much any PMS symptom. Lowering the dose might help considerably. There are lots of good sites on the net about HRT drugs. Give them a look. It is a pain to find just the right combination of drugs that have the least side effects. Keep working with the doctor and don't be afraid to speak up. Good luck to you. I hope you get your issues resolved.