KathleenHope you see this. I was on Lotronex soon after if first came out. It did WONDERS for me, and I was highly upset when it was taken off the market. My symptoms returned: diarhea, gut gurgling, urgency - but no blood. Then in 2004 or so, blood appeared. I had my first colonoscopy and was dx UC. I am now on Asacol.I am also in a UC flare up and desperate, and I am wondering if Lotronex would help me again. It worked sooo well. As a biologist, any comments? Thanks