I see that it has been awhile since anyone has been on this thread. Hopefully, I will generate some additional conversation. I am a surgical assistant, so I may able to help some people with medical questions. But, I am hoping I can get helped with my dilemma. In the last year and a half my weight has crashed from 210 to my current weight of 149. I seem to plateau and then crash again. I was running at 160-165 for most of last fall. Then from December and until now I went on another weight loss spell, going from that 160-165 to 149-152. I am fatigued and have very severe bouts of abdominal cramping with occasional symptoms of watery diarrhea. There have been times, not always though, when I would get a rash on both legs when I had the abd. pain and diarrhea. Most times I have not had the rash with it. My biggest concern is how ill I feel and how much weight I am losing. I am a 6' 1" male who has not weighed under 150 since I was in my early teens. My ideal weight is around 175-180. I am always hungry. I feel like I am starving. I force myself to eat so I know I am getting the appropriate amount of calories. But, these lower abdominal cramps are awful and is getting more and more difficult knowing I might have to face a bout of that severe pain whenever I eat. I have been tested both with blood work and an EGD (upper scope) to rule out Celiac disease. I had the Endomysial IGA and the TI IGA test and was told it was not Celiac. The mistake I made was getting off of Gluten on my own. Before the endoscopy and blood work, which is a no-no. Since the small bowel regenerates in as little as three days you can have false negatives. My big problem is that both of the GI docs who I have gone to, both friends and former colleagues, from the get-go poo-pooed even the proposition that I have Celiac Disease. I have read in scientific literature that there are scores of people who have been wrongly ruled-out for Celiac. I have also met quite a few older, 35+, who were told that they "did not" have Celiac disease only to find a sharp doctor out there who ended up diagnosing them with CD and changing their lives for the better. God knows I do not want to have ANY disease. I have battled back from multiple spinal cord surgeries and am working on getting either my medical degree or a degree as a Physician Assistant. This being so sick is not helping at all. Now being just under 150 is just way to much weight loss. I look very ill. Both my buddies have the thinking that it is a malignancy. I am now being checked for Carcinoid Tumor/Syndrome, which can have very similar signs and symptoms. But, I just have this feeling it is not a Carcinoid Tumor. I honestly think it is Celiac or Crohns. Any comments or advice would surely by appreciated.Believe or not, my expertise is in Gastroenterology. I am only an assistant, with a degree in Surgical Technology. So, of course I am not as "smart" as my pals with the medical degree. But, I do know my own body and losing all this weight and feeling so awful sure is an indication that something is wrong. I hate that I elminated Gluten from my diet before my biopsy and blood tests. I think I need to re-introduce fully to my diet and get re-tested. Any opinions out there?I read another post asking where the biopsy was taken. When you do an "upper endoscopy," the scope goes through the esophagus into the stomach through the pylorus, and then to the second part of the duodenum (first part of the small intestines). Multiple biopsies are taken in the duodenum, especially when trying to microscopically assess the small intestines looking for tissue changes for things like Celiac Disease. The tissue taken is very small. It could fit on the fat end of a large sewing needle. Other possible biopsy sites are the stomach and esophagus are taken, which assesses for gastritis, GERD, or any other possible malignant or pre-malignant changes. Many times a biopsy is taken to see if you have the presence of a bacteria called heliobacter pylori. I can answer any "general" questions about that if needed. I really hate the fact I am having this major health issue, and I am in the medical field. Even worse, I am not getting the answers. Hopefully, this site will be a great support system.