I have suffered with IBS-D for 27 years. Last June I decided to give Immodium one more chance. I started taking 2 in the Am and 2 at night. It worked miracles. I have not had cramps or D until 2 nights ago. I was so disappointed when this happened. I have not had another attack since, but I haven't felt right for the past 2 days. I haver taken extra doses of Immodium, but I still don't feel back to normal. I am continuing to take Immodium. Has anyone else had this experience and do you think the immodium will kick back in? I felt so good for the past 6 months. I really thought I had found the cure.