I was on prilosec/omeprazole for several years (for GERD) before my IBS hit. I'm still on it now. Does anyone know if long-term use of such PPI's are implicated in triggering IBS? I've heard there might be some connection to SIBO.I did stop the pills for a couple weeks one time (almost killed me to do it) but I didn't notice any improvement in my IBS. Maybe the damage is done? Maybe it takes much longer to heal? Maybe I might do better switching to a different PPI?