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http://www.greatplainslaboratory.com/fibromyalgia2.html FibromyalgiaYeast Byproducts in Fibromyalgia Patients Fibromyalgia & Yeast (page 1) Tartaric acid? Where the Yeast is and Why it Causes Problems Figure 1 - Tartaric Inhibition in the Krebs Cycle Figure 2 - Effects of Nystatin on Urine Tartaric Acid Contributing Factors (page 2) Figure 3 - Factors that Contribute to Yeast Overgrowth Testing - What to Expect, and How it can Help Frequently Asked Questions About Yeast Testing Notes on Our Testing from the book Detoxification and Healing: The Key to Optimal Health References Order a Test Kit Contributing FactorsMost of the time the yeast are present only in the intestinal tract, not in the blood and other organs. However, the tartaric acid and other compounds produced by yeast in the intestine are absorbed into the bloodstream and may enter all of the cells of the body.Dr. St Anand noticed that patients with fibromyalgia had high amounts of dental tartar on their teeth and speculated that similar deposits in the muscles and ligaments might be causing the pain of fibromyalgia. It's possible that tartaric acid is the compound found in the dental tartar and that crystals of this substance may be causing the muscle and joint pain, just as kidney stones cause kidney pain. The two main causes of the yeast overgrowth are use of broad-spectrum antibiotics and the high sugar and carbohydrate content of the American diet (Figure 3). These antibiotics kill most of the normal bacteria (germs) in the intestinal tract, but do not kill organisms such as yeast (8-15). As a matter of fact, some yeast grow faster in the presence of antibiotics. The reason fibromyalgia commonly follows traumatic accidents may be related to the use of antibiotics to treat trauma. Sugar consumption is the second major factor in causing yeast-related illnesses. The average American consumes 10 times more sugar than Americans in the time of George Washington(about 150 lb per year). In a study done in mice, those mice receiving sugar in their water had 200 times more yeast in their intestine than mice receiving plain water (16). Other factors that cause yeast overgrowth may include stress, birth control pills, viral infections, and a weak immune system.Testing - What to Expect, and How it can HelpSome doctors assert that everyone has yeast in their intestine, and if yeast were the cause of fibromyalgia, everyone would suffer from fibromyalgia-like symptoms. However, the important question is not about the presence of yeast. The critical factors are the quantity of yeast and the kinds and amounts of toxic products they produce.To illustrate: everyone in our society has carbon monoxide in their blood and can tolerate a low value. However, when the amount of carbon monoxide increases, some individuals feel depressed, some have headaches, some develop muscle weakness, some feel tightness in the chest or angina, some experience nausea and vomiting, some become dizzy, and some develop dimming of vision. As amounts of carbon monoxide increase, symptoms may include convulsions, coma, respiratory failure, and death. Individuals who recover from severe carbon monoxide poisoning may suffer residual neurological damage. Different people will respond with different symptoms to the same concentration of toxins. So why would it be surprising that exposure to a wide range of toxic yeast products--at different times and at different ages--might produce different symptoms? No one would challenge a suggestion of a connection between carbon monoxide and all of the diverse symptoms associated with carbon monoxide exposure. That connection is accepted because carbon monoxide is easily measured in blood. The toxic yeast products were just discovered, but as knowledge of them increases, acceptance of the yeast-related illnesses will increase. As the philosopher Schopenhauer said, "All truth goes through three stages. First, it is ridiculed. Then, it is violently opposed. Finally, it is accepted as self-evident." Within five years, people who ignore the importance of yeast-related illness will be in the same camp with those in the Flat-Earth Society. TopFrequently Asked Questions About Yeast TestingWhat can I do about this problem if I have it? The yeast problem can be treated with a combination of a low sugar/low carbohydrate diet, an antifungal drug to kill the yeast, and probiotics, which are supplements of Lactobacillus acidophilus to restore beneficial bacteria to the intestinal tract. Malic acid and magnesium supplements will help the patient until the yeast problem is resolved (which may take about two months). The reduction in tartaric acid in urine following antifungal treatment is illustrated in Figure 2.Top |OrderWhat other information will I get from your test? The test evaluates inborn errors of metabolism that can be detected with this technology (called GC/MS, such as PKU, maple-syrup urine disease, and many others). In addition, we check for other problems such as vitamin deficiencies and the abnormal metabolism of catecholamines, dopamine, and seretonin We currently quantitate 62 substances, but also evaluate other substances that are not quantitated. For example, in one report, high kynurenic acid indicated a need for vitamin B-6, and an elevated glutaric acid indicated a requirement for coenzyme Q-10. Even if you don't have the yeast problem, our test may still be beneficial to you!Top |OrderHow do I get the test done? A medical practitioner who is licensed to order urine testing in your state must approve the test order. Regulations vary from state to state so an approved medical practitioner could be a medical doctor (MD), osteopath (DO), nurse practitioner, chiropractor (DC), or naturopath (ND). If you have difficulty in getting your physician to approve the test, we can refer you to a physician in most locations in the United States and in some foreign countries. The test is reimbursed by most insurance companies but, of course, we cannot guarantee reimbursement. The test requires that a morning urine sample be shipped to The Great Plains Laboratory, and results are usually available within two weeks, including a recommendation to your physician for treatment.Top |OrderWill drugs or nutritional supplements interfere with the test?No, there is no interference from any known drug or supplement. The malic acid and magnesium products will not affect the test results.However, if antifungal supplements or drugs are taken before the test, you will probably get a lower value for the yeast byproducts. We advise you to get the test first so that you will know what the starting point is. Top |OrderI have been disabled due to the severity of my fibromyalgia, but have not been able to get benefits. Could this test help me to get benefits?This test could benefit you if we document a defined biochemical disorder. Of course, more important is the possibility of reversing the fibromyalgia if the yeast problem is a significant factor.Top |OrderWhat can I do if my physician doesn't understand the test results? We will be glad to help you and your physician develop a suitable therapy based on your test results.Top |OrderI have an HMO, and they have to send the test to a certain lab. Is that okay? Unfortunately, no. There is no other laboratory that routinely analyzes the same compounds as this laboratory (including Labcorp, SmithKline, or Mayo Medical laboratories). If you do not specify our laboratory, your urine will be sent to one of the large reference labs which cannot accurately evaluate your condition. Most of these labs only test for inborn errors of metabolism.Top |OrderWhat about reimbursement for Medicaid and Medicare? We are set up for Medicare, but we do not yet have Medicaid authorization.Top |OrderI don't have insurance and can't afford the price. Can you help me? We would be happy to work out an installment plan for you. We can also accept MasterCard and VISA payments. Top |OrderNotes on Our Testing from the Book Detoxification and Healing: the Key to Optimal Health"Dr. Shaw's work is very recent and as I write this he has just opened a new lab… The reason for telling you about his work is to ask you to think about the implications and watch as his ideas develop over the next few years. As you will see...there is other evidence to support these ideas and, if you understand the implications, there are things you can do now that will reduce your risk of ill health while continuing to watch from the sidelines." Dr. Baker, the author of Detoxification and Healing, is a graduate of Yale University School of Medicine and is board certified in obstetrics and pediatrics. Dr. Baker was director of the Gessell Institute of Human Development and has taught at Yale Medical School, and is the author of dozens of articles and several books about health and nutritional biochemistry. (Return to page 1.)Top |OrderReferences 1. Crook William. The Yeast Connection Handbook.
Jackson,TN,1997:34-35. 2. "Tartaric acid." Microsoft Encarta 96 Encyclopedia on CD ROM. 3. Webster R. Legal Medicine and Toxicology. WB Saunders, Philadelphia, 1930: 413-414. 4. Shaw W, Kassen E, and Chaves E. "Increased excretion of analogs of Krebs cycle metabolites and arabinose in two brothers with autistic features." Clinical Chemistry 41:1094-1104, 1995. 5. Mahler H and Cordes. Biological Chemistry. New York, Harper and Row. 1966: 417-418. 6. Holzschlag Molly. "CoQ10, malic acid, and magnesium may improve CFIDS/FM symptoms." The CFIDS Chronicle, Summer 1993. 7. St Amand RP. "Exploring the fibromyalgia connection." The Vulvar Pain Newsletter. Fall 1996, 4-6. 8. Kennedy M and Volz P "Dissemination of yeasts after gastrointestinal inoculation in antibiotic-treated mice." Sabouradia 21:27-33, 1983. 9. Danna P, Urban C, Bellin E, and Rahal J. "Role of Candida in pathogenesis of antibiotic associated diarrhea in elderly patients." Lancet 337: 511-14, 1991. 10. Ostfeld E , Rubinstein E, Gazit E, Smetana Z. "Effect of systemic antibiotics on the microbial flora of the external ear canal in hospitalized children." Pediat 60: 364-66, 1977. 11. Kinsman OS, Pitblado K. "Candida albicans gastrointestinal colonization and invasion in the mouse: effect of antibacterial dosing, antifungal therapy, and immunosuppression." Mycoses 32:664-74,1989. 12. Van der Waaij D. "Colonization resistance of the digestive tract-mechanism and clinical consequences." Nahrung 31:507-17, 1987. 13. Samonis G and Dassiou M. "Antibiotics affecting gastrointestinal colonization of mice by yeasts." Chemotherapy 6: 50-2, 1994. 14. Samonis G, Gikas A, and Toloudis P. "Prospective evaluation of the impact of broad-spectrum antibiotics on the yeast flora of the human gut." European Journal of Clinical Microbiology & Infectious Diseases 13:665-7, 1994. 15. Samonis G, Gikas A, and Anaissie E. "Prospective evaluation of the impact of broad-spectrum antibiotics on gastrointestinal yeast colonization of humans." Antimicrobial Agents and Chemotherapy 37: 51-53, 1993. 16. Vargas S, Patrick C, Ayers G, and Hughes W. "Modulating effect of dietary carbohydrate supplementation on Candida albicans colonization and invasion in a neutropenic mouse model." Infection and Immunity 61:619-626,1993.