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FYI:Central Fear Circuits Less Activated in IBS Patients SAN DIEGO, CA, May 22 (Reuters Health) - The threat of visceral discomfort appears to evoke an emotional rather than fearful response in patients with irritable bowel syndrome (IBS), researchers report at the annual Digestive Disease Week meetings held here. Dr. Bruce D. Naliboff, of UCLA Medical Center, in Los Angeles, with colleagues there and at UC Irvine Medical Center, performed a PET study of 12 IBS patients and 12 controls to examine the brain response associated with the fear of anticipated visceral discomfort. Brain scans were obtained on all subjects at baseline, during moderate rectal distension and during expected but undelivered noxious distension. "Although we know that IBS is exacerbated by stress, we conducted this study to learn more about the connection between the disease and brain function," Dr. Naliboff said in an interview with Reuters Health. Brain scans showed that controls had "greater baseline activity in mid anterior cingulate cortex (ACC), and greater activation in the perigenual mid ACC, lateral prefrontal cortex, thalamus, periaqueductal grey and medullary regions" than did IBS patients. During visceral stimulation, "IBS patients showed greater activation in mid anterior cingulate cortex as well as posterior cingulate," compared with controls, the researchers note. They found that expected but undelivered rectal discomfort activated the central fear circuits in the controls. IBS patients showed "less activation of the fear circuits but greater activity in posterior cingulate cortex." "Our findings indicate that the parts of the brain that respond in IBS patients are the same parts of the brain involved in processing emotionally charged information," Dr. Naliboff said. "These data give us a better understanding of this stress-related disorder and may provide information about potential new medication targets," he explained. "This brain imaging study is one of a series examining IBS, dyspepsia and fibromyalgia," Dr. Naliboff added. ------------------ http://webpotential.com/ericibs/index.htm
 

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Thanks for the post but I see that once again the doctors refer to IBS as a stress- related disorder. Why do they try to simplify IBS when it's not for so many of us.
 
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